Erectile dysfunction drugs blog.

If erection problems could be caused by a
prescribed medication, it may be possible to change
the dose or try another medication. Do not change or stop taking any medication
without first talking with your health professional.

Medication Choices

Commonly used oral medications include:

• Phosphodiesterase-5 inhibitors (PDE-5
  inhibitors) such as Viagra, Levitra, and Cialis.

Other medications that may be used include:

• Injected medications.
• Intraurethral alprostadil (MUSE).

Hormones and other medications may be prescribed for
men who have low
testosterone or high
prolactin levels.

Some men have tried
yohimbine-a ed medicine
medication that should not be
confused with the dietary supplement yohimbe-to treat erection problems.

For more information on medication choices, see:

Should I use phosphodiesterase-5 inhibitors
(such as Viagra, Levitra, or Cialis) for erection
problems?

Should I use injections for erection
problems?

What To Think About

PDE-5 inhibitors and heart problems

Health experts have debated the use of PDE-5 inhibitors in men
with heart disease, because deaths have been reported after use of Viagra. The
1999 American College of Cardiology/American Heart Association (ACC/AHA) Expert
Consensus Document noted that PDE-5 inhibitors may be dangerous for people
who:³

• Have
  coronary artery disease (CAD).
• Have
  heart failure and low blood pressure.
• Are
  taking many different drugs for
  high blood pressure.

However, several more recent studies have reported that some
men with heart problems may be able to take PDE-5 inhibitors safely. Talk to
your health professional about whether PDE-5 inhibitors are appropriate for
you.

• One study found no evidence of increased
  risk for
  heart attack or CAD in men who use Viagra.⁴
• Another study in men with CAD reported that
  Viagra does not lead to heart attack and that heart attacks and other
  ed tabs
  problems reported after taking Viagra may be related more to the
  physical activity of intercourse than to the medication.⁵
• A study of 35 men found that Viagra is safe for
  men with moderate heart failure.⁶

Sexual activity is exercise. If you have a heart condition and
have not been sexually active for a while, talk with your health professional
to make sure you can engage in sexual activity safely.

PDE-5 inhibitors should never be used if
you may need to take a
nitrate-containing medication, such as viagra vs cialis
.
Taking nitroglycerin and a PDE-5 inhibitor within 24 hours of each other may
greatly lower your blood pressure, which could lead to a heart attack,
stroke, or death.

If you are taking a PDE-5 inhibitor and are going to have a test
for heart disease, be certain your doctor knows you are taking it. You should
not take a PDE-5 inhibitor for 24 hours before the test. If you develop a
problem during the test, nitrate-containing medications such as nitroglycerin
may be used.

Although oral medications for erection problems can be purchased over the Internet, you should still talk with your health professional before using this medication. This is especially important if you have a heart problem.

If you are using a combination of drugs for high blood pressure,
PDE-5 inhibitors could result in low blood pressure (hypotension). Also for
this reason, you should not take alpha blockers-used to lower blood pressure
and to treat an enlarged prostate-with these medications without talking to
your health professional; the combination could cause a dangerous drop in blood
pressure.

Although the antidepressant medication trazodone has been used
for treating erection problems, there is no current evidence that it is
effective for this purpose.¹

Medication Choices

Estrogen. If you only have vaginal
dryness and irritation (and not other symptoms such as hot flashes), you can
use a limited amount of
estrogen in a cream, tablet, or ring in the vagina.
The daily estrogen makes your tissue less thin and sensitive and more moist.
Many women find that using a cream or tablet twice a week is enough. This may
increase vaginal tone and lubrication, which will decrease
vulvar dryness, irritation, and shrinkage (atrophy).

If you also have other
menopausal symptoms that affect physical and mental
well-being, talk to your health professional about taking daily (systemic)
estrogen therapy.
Estrogen can increase the blood flow in the
vagina, as well as reduce hot flashes and other
symptoms of
menopause.
Estrogen therapy or
estrogen-progestin therapy can be oral (pills),
vaginal, or transdermal (with a patch). In a small number of women, hormone
therapy causes heart disease, breast cancer, dangerous blood clots, stroke, and
dementia. Talk to your health professional about whether this therapy is right
for you.

Testosterone. This hormone may play a part
in a woman’s sex drive and satisfaction. The ovaries make
testosterone throughout a woman’s lifetime. Women have
the most testosterone in early adulthood; testosterone levels drop by half
between the early 20s and the early 40s.

In women who have their ovaries removed (oophorectomy),
testosterone drops by 50%.¹⁰ If you have had an
oophorectomy, your health professional may suggest trying
testosterone therapy. But the U.S. Food and Drug
Ed tablets
(FDA) has not approved any testosterone therapy for women.

What To Think About

The generic soft tab viagra
-estrogen formula called Estratest is
not approved by the FDA. The company that makes it
markets it for moderate to severe
menopausal symptoms. It is also prescribed to some
menopausal women to improve sexual desire and
response. But Estratest is made with
methyltestosterone, which the body uses differently than testosterone. It does
not directly raise the amount of testosterone in your body. And, taking a
testosterone by mouth does put you at risk for problems with your liver and
possibly your heart. Using a patch or cream does not.

At this time, there is no testosterone pill, patch, or cream
approved for women-those made for men have too high a dose for women. Side
effects of too much testosterone include acne, facial hair, and loss of hair
and a deepening of the voice, which may be permanent.

No studies have looked at the benefits and risks of taking
testosterone for longer than 6 months. The long-term effects of testosterone
therapy in women are not known.¹⁰

Sildenafil (Viagra) is used to treat
erectile dysfunction in men. The maker of this
medicine has decided not to market it for improving women’s sexual desire and
arousal. This was based on research showing that sildenafil was not effective
for most women. The maker has commented that women’s sexuality is a complex mix
of physical, emotional, and relationship factors, and it is not as simple to
treat with a medicine as male erectile dysfunction is.¹¹

Currently no medications are approved by the FDA to treat female
sexual problems, although several paths are being studied, including
stimulation of certain molecules (receptors) in the brain and increasing blood
flow to the genitals. It is still too early in the process to know whether any
of these medications will prove to be effective and safe treatment
options.¹²

Nov. 16, 2005 — A drug called Revatio may help treat an aggressive condition called pulmonary arterial hypertension.

Patients with pulmonary hypertension have elevated blood pressure in the pulmonary (lung) blood vessels. The condition often arises from lung problems, but some cases are without a known cause. It can result in heart failure and early death.

Unfortunately, most of the medications that are used to treat this serious condition are not easy to take and are given by IV, injection, or generic soft tab viagra
— with real risks of unwanted side effects.

Revatio has the same active ingredient — erectile dysfunction medication
— as Viagra. Revatio and Viagra are made by Pfizer.

Pfizer funded the new study, which appears in The New England Journal of Medicine. Pfizer is a WebMD sponsor.

The researchers included Nazzarene Galie, MD, of the cardiology institute at Italy’s Dysfunction erectile pill
of Bologna.

Walking Test

The study lasted for 12 weeks. It included 278 patients with pulmonary hypertension. The patients lived in the U.S., Mexico, South America, Europe, Asia, Australia, South Africa, and Israel.

Three times daily, the patients took Revatio (20, 40, or 80 generic viagrageneric viagra
) or an empty drug (placebo) orally. That was in addition to any other standard pulmonary hypertension medications.

The big question was how far patients could walk in six minutes. That’s an important exercise test for patients with pulmonary hypertension. The farther patients can walk, the better.

Walking Farther

All of the patients taking Revatio walked farther at the end of the study:

• 20-milligram group: Walked about 148 extra feet (a 13% increase).
• 40-milligram group: Walked about 151 extra feet (a 13% increase).
• 80-milligram group: Walked about 164 extra feet (nearly a 15% increase).

Higher doses didn’t bring a notable increase in distance walked, the researchers report.

Patients were then allowed to take Revatio for up to a year; 230 did so. The researchers looked at the walking tests of 222 of those who were only taking Revatio as treatment. After a year, they walked about 167 extra feet, on average, compared with the beginning of the study.

How Patients Fared

Most of the patients included in the study had milder stages of pulmonary hypertension. Few cases worsened, regardless of treatment type, the study shows.

Patients taking Revatio weren’t any more or less likely to have their symptoms worsen during the trial.

The study wasn’t designed to see if Revatio helped patients live longer. Four died during the study. No deaths were judged to be linked to the treatments, write the researchers.

Side effects seen with Revatio were mild or moderate and included headache, flushing, muscle pain, and diarrhea, report Galie and colleagues.

July 24, 2006 — Like Viagra before it, a drug once studied to treat heart problems may help treat sexual dysfunction. But this time it’s being tested exclusively for women.

A new study shows that a modified version of the experimental heart drug Candoxatril was effective at increasing blood flow to the vagina in animal tests.

If further research confirms these results in humans, the drug may be used to treat female sexual arousal disorder (FSAD).

Researchers say an estimated 40% of women suffer from FSAD or other forms of sexual dysfuction, such as low libido or pain during intercourse.

Candoxatril went into clinical trials in the 1990s as a heart failureheart failure ed pills
but has since become the focus of efforts to develop a medication to treat female sexual arousal disorder.

How the Drug Works

Candoxatril is one of several compounds that targets levels of vasoactive herbal cure for erectile dysfunction peptide (VIP), which controls blood flow to the vagina. Researchers say decreased blood flow to the vagina is thought to be a key factor in female sexual arousal disorder.

An enzyme called NEP degrades VIP in the body, and Candoxatril works by blocking NEP.

In a new study, published in the Journal of Medicinal Chemistry, erectile dysfunction answers
altered the molecular structure of Candoxatril in order to focus the drug to treat female sexual arousal dysfunction.

In animal tests, researchers at Pfizer Global Research and Development in the U.K., found the new compound effectively blocked NEP, took effect quickly, and the effect lasted for a relatively short time.

They say the results suggest that the drug might have similar effects in humans, but further research is needed.

Nov. 7, 2005 - The drug made famous for its treatment of erectile pills
appears to have another 100 90 generic viagra
use.

A study in the journal Ed pills
suggests Viagra could help treat a circulatory disorder called Raynaud’s phenomenon, which affects about 5% of the population. Raynaud’s phenomenon can be associated with other diseases such as lupus.

Raynaud’s phenomenon causes episodes of numbness, tingling, and pain in the fingers and toes, as well as skin sores or gangrene in severe cases. The attacks are spawned by spasms in small blood vessels in response to cold temperatures or emotional stress.

These spasms cause blood vessels to constrict and compromise blood flow to distal areas such as toes and fingers. The disorder is sometimes treated with medications to relax the blood vessels, but this is not always successful.

The Viagra study involved 18 patients (mostly women) whose Raynaud’s symptoms were not responsive to conventional therapies. While taking Viagra twice a day for four weeks, the patients experienced improved blood flow in the dysfunction pills
and fewer Raynaud’s attacks. Symptoms improved and the duration of attacks was also shorter. In those who had skin sores, the ulcers began to heal visibly.

These effects did not occur while patients were taking a placebo. At the end of the study, 16 of the participants asked to continue taking Viagra off-label (that is, for a purpose other than its FDA-approved use).

Viagra causes blood vessels to dilate in a different way from other vasodilating drugs, which may explain why it helped Raynaud’s patients who didn’t respond to standard treatments. The researchers conclude that drugs like Viagra could offer “a promising new approach in patients with microcirculatory disorders.”

Although Viagra has risk for serious side effects such as heart attack, stroke, and vision loss, none of the study participants reported any such adverse effect. The side effects reported by study participants included headache, muscle pain, flushing, mild nausea, dizziness, and nasal congestion.

One of the researchers has served as a consultant and speaker for Viagra’s manufacturer, Pfizer. Pfizer is a WebMD sponsor.

Feb. 23, 2006 — Researchers in the U.K. have a new theory to explain the cause of Crohn’s disease, and they say cheap sildenafil citrate like the erectile dysfunction drug Viagra may prove useful for treating the bowel disorder if they are right.

In Crohn’s disease, chronic inflammation causes ulcers within the digestive tract that can lead to severe gastrointestinal symptoms, including abdominal pain, persistent diarrhea, and rectal bleeding.

The most widely accepted theory is that an overactive immune system causes the damaging inflammation. But researchers from the University College London say the opposite appears to be true.

They believe a weaker-than-normal immune response triggers the bowel inflammation that leads to Crohn’s disease. Their research appears in the Feb. 25 issue of The Lancet.

1 Disease, 2 Theories

The prevailing theory of Crohn’s disease is that the body’s immune system reacts abnormally in people with the disorder, producing chronic inflammation that leads to bowel injury.

Tony Segal, professor of medicine at University College London, explains the weak immune system theory like this: “The wall of the bowel is normally an effective barrier against the bowel contents, but sometimes the barrier is broken by an infection or injury and the bowel contents, which include large numbers of bacteria, penetrate into the bowel wall.

“Normally, an acute inflammatory response would kick in to remove the bacteria and return the condition of the bowel to normal. But in Crohn’s disease, we think that the acute inflammation fails to kick-start, leaving bacteria to fester in the bowel wall which, in turn, triggers chronic, secondary inflammations.”

Segal and colleagues conducted a series of small experiments that measured white blood cell production in response to intestinal and skin trauma in both Crohn’s patients and healthy patients. With inflammation, white blood cell numbers are expected to rise. In one experiment, researchers injected a killed gut bacteria into the forearms of patients and healthy participants to study blood flow and immune response.

They found that the Crohn’s patients produced erectile dysfunction medicine
lower levels of white blood cells and proteins involved in inflammation, compared with people without the disorder.

Segal tells WebMD that people who carry a gene that has been linked to Crohn’s disease may be especially vulnerable to getting the disease if they have weak immune systems.

He added that drugs like Viagra, which open the blood vessels and increase blood flow, may help.

The Viagra Response

The researchers tested this theory by treating 10 Crohn’s patients with 50 milligrams of Viagra after injecting them with the killed gut bacteria. They found that blood flow to the infected area improved.

“Increasing blood flow is an important part of the inflammatory response, and that is why this drug may work,” Segal says. “But we don’t yet know if this will give rise to successful treatment. We need to study this further to find out.”

Segal and colleagues are among a growing number of researchers suggesting that a weak immune system, rather than an overactive one, is largely responsible for Crohn’s disease, says University of Chicago associate professor of medicine Sunanda Kane, MD.

She adds that the new research adds authentic generic viagra vs
to the theory but does not prove it.

“This is a little more evidence that maybe we have been barking up the wrong tree,” she tells WebMD. “The idea that we should be strengthening the immune system — rather than suppressing it — sounded a little crazy at first, but the evidence continues to come in. But we still have a long way to go to really understand what causes Crohn’s.”

Biologic agents that stimulate a specific part of the immune system are now being tested in Crohn’s patients. If such treatments prove effective, Kane says doctors would have an effective alternative to steroids, which work well for many patients but have many side effects.

“For decades now suppressing the immune system with steroids has worked, and we will continue to do so until we find alternatives that work for everybody and are risk-free,” she says.

Oct. 25, 2006 — Viagra may ease blood pressure in the lungs of people with chronic obstructive pulmonary disease (COPD).

That’s according to a small Dutch study presented in Salt Lake City at Chest 2006, held by the American College of Chest Physicians.

COPD is the No. 4 cause of death in the U.S. and worldwide, according to the National Heart, Lung, and Blood Institute (NHLBI).

COPD is a lung disease in which breathing is difficult. It’s usually caused by smoking cigarettes, but it can also be caused by other lung irritants.

The disease develops slowly and may take years to show symptoms, which include:

• Cough
• Sputum (mucus) production
• Shortness of breath (levitra vs cialis
  with exercise)
• WheezingWheezing
• Chest tightness

Those symptoms may or may not indicate COPD, states the NHLBI’s web site.

Viagra Study

The Viagra study included 12 COPD patients, half of whom had high blood pressurehigh blood pressure in the pulmonary artery, which brings blood to the lungs. The development of pulmonary hypertensionpulmonary hypertension is a erectile dysfunction
of COPD, but not everyone with COPD will develop it.

The cialis vs viagra
included Sebastiaan Holverda, MSc, of Erectile dysfunction drugs
University Medical Center.

They tracked the patients’ pulmonary artery blood pressure before and after taking Viagra.

Why Viagra? It relaxes (dilates) blood vessels, lowering blood pressure and helping blood to flow.

First, the patients rested. Then they pedaled a stationary bike for three minutes at a mild pace.

As expected, pulmonary artery blood pressure was higher during exercise, since the lungs were working harder.

Next, the patients took a Viagra pill, waited 45 minutes, and repeated the rest and exercise tests.

Their pulmonary artery blood pressure during exercise was lower after taking Viagra.

“These data suggest that during daily activities some COPD patients may benefit” from drugs that dilate blood vessels, the researchers write.